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pentobarbital will lessen the extent or outcome of cinacalcet by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will lower the level or effect of bosentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.pentobarbital will lessen the level or impact of guanfacine by